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= exceeds 28-day window per reconstitution Solution for maintenance use: reconstitute only ~3.5mg at a time (enough for 3.5 weeks at 500 mcg 2x/week) and leave the rest as powder

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

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Mol Nutr Food Res 51(1):6199

1 2 "Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects"